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KMID : 0981820080280030174
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Korean Journal of Laboratory Medicine
2008 Volume.28 No. 3 p.174 ~ p.178
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Two Cases of Trisomy 19 as a Sole Chromosomal Abnormality in Myeloid Disorders
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Jung Soon-Il
Cho Hee-Soon
Kim Min-Kyoung
Hyun Myung-Soo
Lee Kyoung-Hee
Hah Jeong-Ok
Lee Chae-Hoon
Kim Kyung-Dong
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Abstract
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Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary abnormality: however, trisomy 19 rarely occurs as a sole chromosomal abnormality and, to date, it has only been reported in 48 hematopoietic malignancies, 1 case of adenocarcinoma and 1 case of astrocytic tumor. Here, we report two additional cases of trisomy 19 as a sole karyotypic aberration in myeloid malignancies. One of these cases involved a 6-month-old male who was diagnosed with acute myeloid leukemia minimally differentiated. His karyotype was 47,XY,+19[20]. He expired 5 days after diagnosis. Another case occurred in an 80-yr-old female who had refractory anemia with excess blasts. Her karyotype was 47,XX,+19[16]/46,XX[4]. Four months later, her peripheral blood smears suggested that the disease had progressed, but she refused further evaluation. Based on a review of the existing literature and the results of this report, trisomy 19 not only as a secondary abnormality but also as a sole karyotypic aberration is strongly associated with myeloid disorder;
however, it is not preferentially found in specific FAB subgroups of myelodysplasic syndrome or acute myeloid leukemia.
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KEYWORD
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Trisomy 19, Sole chromosomal abnormality, Myeloid malignancies
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